SidaGhanaV1, Main, Exploration, bibRecord, 000402

A re-evaluation of the origin of hepatitis C virus genotype 2 in West Africa

Identifieur interne : 000402 ( Main/Exploration ); précédent : 000401; suivant : 000403

A re-evaluation of the origin of hepatitis C virus genotype 2 in West Africa

Auteurs : Michael A. Purdy ; Joseph C. Forbi ; Amanda Sue ; Jennifer E. Layden ; William M. Switzer ; Ohene K. Opare-Sem ; Richard O. Phillips ; Yury E. Khudyakov

Source :

The Journal of General Virology [ 0022-1317 ] ; 2015.

RBID : PMC:4681065

Descripteurs français

KwdFr :
- Afrique de l'Ouest (épidémiologie), Données de séquences moléculaires, Génotype, Hepacivirus (), Hepacivirus (génétique), Hepacivirus (isolement et purification), Humains, Hépatite C (virologie), Hépatite C (épidémiologie), Phylogénie, Variation génétique.
MESH :
- génétique : Hepacivirus.
- isolement et purification : Hepacivirus.
- virologie : Hépatite C.
- épidémiologie : Afrique de l'Ouest, Hépatite C.
- Données de séquences moléculaires, Génotype, Hepacivirus, Humains, Phylogénie, Variation génétique.

English descriptors

KwdEn :
- Africa, Western (epidemiology), Genetic Variation, Genotype, Hepacivirus (classification), Hepacivirus (genetics), Hepacivirus (isolation & purification), Hepatitis C (epidemiology), Hepatitis C (virology), Humans, Molecular Sequence Data, Phylogeny.
MESH :
- geographic , epidemiology : Africa, Western.
- classification : Hepacivirus.
- epidemiology : Hepatitis C.
- genetics : Hepacivirus.
- isolation & purification : Hepacivirus.
- virology : Hepatitis C.
- Genetic Variation, Genotype, Humans, Molecular Sequence Data, Phylogeny.

Abstract

Hepatitis C virus (HCV) is classified into seven genotypes based on genetic diversity, and most genotypes have been found in Africa. Infections with HCV genotype 2 (HCV2) are most prevalent in West Africa and it was suggested that HCV2 originated in West Africa. To better understand the evolutionary epidemiology of HCV2 in Africa, we examined new NS5B sequences of HCV2 strains obtained from Côte d'Ivoire, Ghana and Nigeria sequenced at the Centers for Disease Control and Prevention with those available from West, North and Central Africa. Bayesian phylogeographic analysis using a discrete trait model showed that Ghana was the most likely geographical region for the origin of HCV2. Spread of HCV2 from Ghana did not appear to be through diffusion to adjacent countries along the coast. Rather, it was transmitted from Ghana to many distant countries in Africa, suggesting that certain routes of geographical dissemination were historically more efficient than mere proximity and that the HCV2 epidemic history in West Africa is extremely complex.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681065

DOI: 10.1099/vir.0.000153
PubMed: 25888623
PubMed Central: 4681065

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p>Hepatitis C virus (HCV) is classified into seven genotypes based on genetic diversity, and most genotypes have been found in Africa. Infections with HCV genotype 2 (HCV2) are most prevalent in West Africa and it was suggested that HCV2 originated in West Africa. To better understand the evolutionary epidemiology of HCV2 in Africa, we examined new NS5B sequences of HCV2 strains obtained from Côte d'Ivoire, Ghana and Nigeria sequenced at the Centers for Disease Control and Prevention with those available from West, North and Central Africa. Bayesian phylogeographic analysis using a discrete trait model showed that Ghana was the most likely geographical region for the origin of HCV2. Spread of HCV2 from Ghana did not appear to be through diffusion to adjacent countries along the coast. Rather, it was transmitted from Ghana to many distant countries in Africa, suggesting that certain routes of geographical dissemination were historically more efficient than mere proximity and that the HCV2 epidemic history in West Africa is extremely complex.</p>
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Le SIDA au Ghana (serveur d'exploration)

A re-evaluation of the origin of hepatitis C virus genotype 2 in West Africa

A re-evaluation of the origin of hepatitis C virus genotype 2 in West Africa

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Le SIDA au Ghana (serveur d'exploration)
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